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John fears the large lump on his neck could become so big that it may eventually suffocate him. Shoshana is depressed because of the big growth on her forehead. Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.
Roger has enormous growths on his nose that drip pus, attract flies and are so large that he can barely breathe. Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.
Tyler's hands are so dry, cracked and painful that he considers getting them amputated. Ebonee covers the tiny bumps around her eyes with sunglasses. Ralph feels like a "cyst factory" with painful cysts covering his back.
With pandemic safety protocols in place, Dr. Lee reopens her office. Monica has a large birthmark growing on the side of her face. Jackie has a melon-sized lump on the back of her shoulder. Reginald has large, rare growths on the back of his head.
Roger returns with his gigantic nose growths in the hopes that Dr. Lee and her colleagues can help before it's too late. Christine has lost her essence due to a large growth on her shoulder. Tiffany has a recurring cyst on her eyelid.
Jason has lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem. Jim has a growth protruding off of his nose, making it hard to breathe.
Margaret's life at 700 pounds is in need of a jump start. At age 35, she is a mama's girl. Now, it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.
At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister. But if he can't find a way to believe in himself, he'll never be able to stop eating.
Margaret's life at 700 pounds is in need of a jump start. At age 35, she is a mama's girl. Now, it's time for Margaret to get out of bed, overcome her food addiction and break away from the comfort of her mother so she can finally live her life.
At 700 pounds, Ontreon has managed to keep going thanks to his faith in God, and he's training to become a minister. But if he can't find a way to believe in himself, he'll never be able to stop eating.
Amy and Michael finally move out of the duplex, while Tammy's partying phase takes a turn for the worse. Amanda tries to get through to her sister before it's too late, and Amy's in for a rude awakening at her annual check up with Dr. Procter.
Amy sees a pediatric dietitian and faces some difficult truths about Gage's diet. Dr. Smith makes a house call and confronts Tammy about her partying lifestyle. While on the road with Chris, Tammy's health hits a dangerous low point.