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A hospital worker feels like she's dying, but doctors can find nothing wrong. A physician's young son is a patient in her own ER, demanding her attention while she's trying to treat others. A woman's hobby of wild mushroom picking sends her to the ER.

An injured ER doctor puts on a show to stop a patient's violent outbursts, and a man’s heart fails as his daughter and girlfriend fight. On Christmas Eve, the family of a patient with severe burns prays for a miracle.

A man with a slashed wrist has a startling secret, and a woman gives birth unexpectedly, shocking the ER staff. A surgeon requires urgent treatment after falling off a bed while trying to help his patient.

Wanda and Ray are extreme hoarders destined to lose their homes and live in isolation if they don't stop surrounding themselves with stuff. Making the change will be emotional and filled with anguish, but they know that time is running out.

For Charlotte and Shelley, hoarding is both a comfort and a curse. If these two women can't find the strength to change, they risk being condemned to a lonely life where possessions replace people.

Joyce’s compulsive collecting almost cost her husband his life, while Norine’s hoarding forced her teenage daughter out of the house and now threatens to destroy what's left of their relationship.

While Patti's extreme hoarding has made it virtually impossible for her daughter to live with her, Jonathan's obsession has kept his three-year-old son from even coming in the door.

Dr. Sandra Lee helps Melissa who has tried to cover a huge lipoma with a sweatshirt for years. Tyler's fear of cancer has kept him from having his huge head lumps diagnosed, Tahj is covered in painful boils and Amber has ear keloids that have taken control of her life.

Dr. Sandra Lee helps Patrick whose nose is covered by huge bumps and he can barely breathe. Aziza and Lauren are friends who bonded over their matching wrist lumps and Joe has a mound in the middle of his forehead that looks like a third eye.

A man suffers from a massive growth on his back that affects his ability to do his job. Then, a patient seeks treatment for debilitating psoriasis that covers 90 percent of his body.

Eric hopes Dr. Lee is able to remove the giant growth from his behind. Breanna suffers from itchy dry skin she can't help but scratch. Michael makes jokes, but he knows the bump on his head is anything but funny.

Leanne's afraid to have her 25-year-old lipoma removed. Jak's undiagnosed skin condition has gone untreated for too long. Trish's nose is changing shape day by day. Carrie has a cyst that is destroying her confidence.

Michelle doesn't recognize her own face. Lee is desperate to have a cyst removed. Ally has a rare skin condition. Gareth has a lipoma on his abdomen.

Pastor Juan's love of food made him overweight, but it has never been a problem until recently, since he's gotten too big to preach and sing to his congregation. If Juan is to help others, he must first help himself by curbing his earthly appetite.

Shakyia was always chubby, but now she has stopped leaving the house and makes no effort. Her older sister rallies her to Houston to meet Dr. Now and lose weight, but she'll be in for a shock when her mom decides that caring for her is just too much.

Pastor Juan's love of food made him overweight, but it has never been a problem until recently, since he's gotten too big to preach and sing to his congregation. If Juan is to help others, he must first help himself by curbing his earthly appetite.

Shakyia was always chubby, but now she has stopped leaving the house and makes no effort. Her older sister rallies her to Houston to meet Dr. Now and lose weight, but she'll be in for a shock when her mom decides that caring for her is just too much.

Tyray discovers shocking info about Carmella. Meisha asks to meet Nicola's family. David spends his first night with Sheila. Gino gets some tough love. Riley's friend warns him about Violet. Christian is off to see Cleo. Amanda and Razvan talk career.